Biosketches

Main Content

Stec Biosketch

BIOGRAPHICAL SKETCH

NAME

David E. Stec

POSITION TITLE

Professor

eRA COMMONS USER NAME

DAVIDSTEC

EDUCATION/TRAINING 

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

University of Scranton, Scranton, PA

B.S.

1991

Biology

Medical College of Wisconsin, Milwaukee, WI

Ph.D.

1996

Physiology

University of Iowa, Iowa City, IA

Post-Doc

1996-2000

Molecular Genetics

Positions and Honors

Positions:

1991-1996: Graduate Student, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI.

1996-2000: Research Fellow, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA.

2000-2001: Assistant Research Scientist, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA.

2001- 2009: Assistant Professor, Director, Transgenic Core, Department of Physiology & Biophysics, University of Mississippi Medical Center, Jackson, MS.

2007:            Tenure

2009-2017: Associate Professor, Director, Transgenic Core, Department of Physiology & Biophysics, University of Mississippi Medical Center, Jackson, MS.

2017-          Professor, Director, Transgenic Core, Department of Physiology & Biophysics, University of Mississippi Medical Center, Jackson, MS.

Honors:

1994-1996: Predoctoral Fellowship, American Heart Association, Wisconsin Affiliate. Mechanism of salt-sensitive hypertension in Dahl S rats.

1995:           Merck Young Investigator Award for Excellence in Cardiovascular Research, American Heart Association Council for High Blood Pressure Research, New Orleans, LA.

1996:           Outstanding Dissertation Award, Friends of the Medical College of Wisconsin, Milwaukee, WI.

1996-1998: Iowa Cardiovascular Interdisciplinary Research Fellowship, Gene targeting of the renin-a angiotensin system via the Cre-loxP recombinase system.

1998-2000: Individual National Research Service Award (NRSA), Department of Health and Human Services. Role of intrarenal renin-angiotensin system in blood pressure regulation.

1998:           Young Investigator Travel Grant, International Society of Hypertension, Amsterdam, Netherlands.

1998:           Outstanding Postdoctoral Poster, University of Iowa College of Medicine, Research Day, University of Iowa, Iowa, City.

2000:           Young Investigator Travel Grant, International Society of Hypertension, Chicago, IL. 2003:              Fellow, American Heart Association

2006:            Co-Chair, AHA Cardiorenal Study Section

2009:            Young Scholars Award- American Society of Hypertension, San Francisco, CA.

2010-11: Co-Chair, AHA National Cardiorenal 1 Study Section 2012-13: Chair, AHA National Cardiorenal 1 Study Section

2019:              Intellectual Property Recognition Award, Office of Research, University of Mississippi Medical Center

2020:              Co-Chair, American Physiology Society Endocrinology& Metabolism Section Featured Topic, "Nuclear Receptors in Metabolism", San Diego Convention Center, San Diego, CA April 5th 2020. (Cancelled due to COVID-19)

2020:              Co-Organizer, Heme Oxygenase and Related Enzymes: From Physiology to Therapeutics, June 28-July 1, Los Angeles, CA. (Cancelled due to COVID-19)

2021:              Chair, American Heart Association Hypertension Peer Review Fellowship Committee

Publications

  1. Stec DE, Tiribelli C, Badmus OO, Hinds TD Jr. Novel function for bilirubin as a metabolic signaling molecule: Implications for kidney diseases. Kidney360 Publish Ahead of Print, 10.34067/KID.0000062022.
  2. Lu Y, Stec DE, Liu R, Ryan MJ, Drummond HA. βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole. J. Physiol. Renal Physiol. 322(5):F498-F511, 2022.
  3. Thomas DT, DelCimmuto NR, Flack KD, Stec DE, Hinds TD Jr. Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: Implications for Heme Oxygenase and Bilirubin. Antioxidants (Basel) 11:179, 2022. PMCID:PMC8868548.
  4. Hinds TD Jr., Kipp ZA, Xu Z, Yiannikouris FB, Morris AJ, Stec DF, Wahli W, Stec DE. Adipose-specific PPARα knockout mice have increased lipogenesis by PASK-SREBP1 signaling and a polarity shift to inflammatory macrophages in white adipose tissue (WAT). Cells, 11(1) 4, PMCID:PMC8750478.
  5. McClung JA, Levy L, Garcia V, Stec DE*, Peterson SJ, Abraham NG. Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications. Pharmacol Ther. 2021 Sep 6:107975 *=corresponding author. PMCID:PMC8958338.
  6. Stec DE, Weigel B, Hinds TD Jr. Editorial: Oxidative stress, antioxidants, transcription factors, and assimilation of signal transduction pathways in obesity-related disorders. Frontiers in Pharmacology. 12:759468. doi: 10.3389/fphar.2021.759468, 2021. PMCID:PMC8452909.
  7. Stec DE and Abraham. NG. Pharmacological and clinical significance of Heme Oxygenase-
    1. Antioxidants (Basel) 10(6):854, 2021. PMCID:PMC8227735
  8. Creeden JF, Gordon DM, Stec DE, Hinds TD Jr. Bilirubin as a Metabolic Hormone: The Physiological Relevance of Low Levels. J. Physiol. Endocrinol. Metab,320(2)E191- E207, 2021.PMCID:PC860361.
  9. Braud L, Pini M, Stec DF, Manin S, Derumeaux G, Stec DE, Foresti R, Motterlini R. Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice. Redox Biology. Jan;38:101805, 2021.PMCID:PMC7721645.
  10. Hinds TD Jr., Creeden JF, Gordon DM, Stec DF, Donald MC, Stec DE. Bilirubin nanoparticles reduce diet-induced hepatic steatosis, improve fat utilization, and increase plasma β-hydroxybutyrate. Frontiers in Pharmacology. Dec 18;11:594574, 2020.PMCID:PMC7775678.
  11. Hinds TD Jr., and Stec DE. Natural product HO-1 inducers as treatment for nonalcoholic fatty liver disease. J. Mol. Sci. 21(24) 9493, 2020. PMCID: PMC7764878.
  12. Shen HH, Alex R, Bellnar L, Raffaele M, Licari M, Vanella L, Stec DE*, Abraham NG. Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary-induced J. Food Biochem. Oct 12;e13522, 2020. PMCID:PMC7770619.*=corresponding author
  13. Hinds TD Jr., Creeden JF, Gordon DM, Spegele A, Britton SL, Koch L, Stec DE. Rats genetically selected for high aerobic exercise capacity have elevated plasma bilirubin by upregulation of hepatic biliverdin reductase-A (BVRA) and suppression of UGT1A1. Antioxidants(Basel) 9:889, 2020. PMCID:PMC7554716.
  14. Raffaelle M, Licari M, Amin S, Alex R, Shen HH, Singh SP, Vanella L, Rezzani R, Bonomini F, Peterson SJ, Stec DE, Abraham NG. Cold press pomegranate seed oil attenuates dietary-obesity induced hepatic steatosis and fibrosis through antioxidant and mitochondrial pathways in obese mice. J. Mol. Sci. 21(15) 5469, 2020. PMCID:PMC7432301.
  15. Shen HH, Peterson SJ, Bellnar L, Choudhary A, Levy L, Gancz L, Sasson A, Trainer J, Rezzani R, Resnick A, Stec DE, Abraham NG. Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection Against Obesity- Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice. Antioxidants(Basel) 9(6):489, 2020.PMCID:PMC7346210.
  16. Gordon DM, Neifer KL, Hamoud AA, Hawk CF, Nestor-Kalinoski AL, Miruzzi SA, Morran M, Adeosun SO, Sarver JG, Erhardt PW, McCullumsmith RE, Stec DE, Hinds TD Jr. Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator-activated receptor α. Biol. Chem. 295(29):9804-9822,2020. PMCID:PMC7380202. 
  17. Stec DE, Gordon DM, Nestor-Kalinoski AL, Donald MC, Mitchell ZL, Creeden JF, Hinds TD Jr. Biliverdin reductase A (BVRA) knockout in adipocytes induces hypertrophy and reduces mitochondria in white fat of obese mice. Biomolecules, 10(3), 2020. PMCID: PMC7175174
  18. Surh YJ, Chung HT, Na HK, Dulak J, Stec DE. Progress in heme oxygenase research. Archives of Biochemistry and Biophysics, 685:108321, May 30, 2020. PMCID:PMC7344117.
  19. Hinds TD Jr., Stec DE. Bilirubin safeguards cardiorenal and metabolic diseases: A protective role in health. Curr Hypertens Rep. 21(11), PMCID:PMC6938163
  20. Stec DE, Gordon DM, Hipp JA, Hong S, Mitchell ZL, Franco NR, Robison JW, Anderson CD, Stec DF, Hinds TD Jr. The loss of hepatic PPARα promotes inflammation and serum hyperlipidemia in diet-induced obesity. J. Physiol. Regul. Integr. Comp. Physiol. 317(5), R733-R745, 2019. PMCID:PMC6879843.
  21. Gordon DM, Adeosun SO, Ngwudike SI, Anderson CD, Hall JE, Hinds TD Jr., Stec DE. CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation. Archives of Biochemistry and Biophysics, 672, 15 September, 2019. PMCID:
  22. Drummond HA, Mitchell ZL, Abraham NG, Stec DE. Targeting Heme Oxygenase-1 in Cardiovascular and Kidney Disease. Antioxidants (Basel) 8(6):181, 2019. PMCID:PMC6617021.
  23. Peterson SJ, Rubinstein R, Faroqui M, Raza A, Boumaza I, Zhang Y, Stec D, Abraham  NG. Positive effects of heme oxygenase upregulation on adiposity and vascular dysfunction: Gene targeting vs. Pharmacologic Therapy. Int J Mol Sci. 20(10): 2514-2527, 2019. PMCID:PMC6566770.
  24. Gordon DM, Blomquist TM, Miruzzi SA, McCullumsmith R, Stec DE, Hinds TD Jr. RNA- sequencing in human HepG2 hepatocytes reveals PPARa mediates transcriptome responsiveness of bilirubin. Physiol Genomics 51(6):234-240, 2019. PMCID:
  25. Stec DF, Henry C, Stec DE, Voziyan P. Changes in urinary metabolome related to body fat involve intermediates of choline processing by gut microbiota. Heliyon 5(4):e01497, 2019. PMCID:PMC6465582.
  26. Bisht K, Canesin G, Cheytan T, Li M, Csizmadia E, Woodruff TM, Stec DE, Bulmer AC, Otterbein LE, Weigel B. Deletion of Biliverdin Reductase A in myeloid cells promotes cytokine expression and chemotaxis in part via a complement C5a-C5aR1 pathway. J Immunol. 202(10):2982-2990, 2019. PMCID:PMC6504595.
  27. Hinds TD Jr., Stec DE. Bilirubin, a Cardiometabolic Signaling Molecule. 72(4):788-795, 2018. PMCID: PMC6205727.
  28. Sundararaghavan VL, Binepal S, Stec DE, Sindhwani P, Hinds TD Jr. Bilirubin, a new therapeutic for kidney transplant? Transplant Rev (Orlando). 32(4):234-40, 2018. PMCID: PMC6535229.
  29. Adeosun SO, Gordon DM, Weeks MF, Moore KH, Hall JE, Hinds TD Jr., Stec DE. Loss of biliverdin reductase-A (BVRA) promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells. J. Physiol. Renal Physiol. 315(2):F323-F331,2018. PMCID:PMC6139518.
  30. Weaver L, Hamoud AA, Stec DE, Hinds TD Jr. Biliverdin Reductase and Bilirubin in Hepatic Disease. J. Physiol. Gastrointest Liver Physiol. 314(6):G668-G676, 2018. PMCID:PMC6032063.
  31. Hamoud AR, Weaver L, Stec DE, Hinds TD Jr. Bilirubin in the liver-gut signaling.Trends in Endocrinology and Metabolism. 29(3):140-150,2018. PMCID:PMC5831340.
  32. Adeosun SO, Moore KH, Lang DM, Nwaneri AC, Hinds TD Jr., Stec DE. A novel fluorescence-based assay for the measurement of biliverdin reductase activity. Reactive Oxygen Species, 5(13):35-45, 2018. PMCID:PMC5785779.
  33. Bakrania BA, Spradley FT, Satchell SC, Stec DE, Rimoldi JM, Gadepalli RS, Granger JP. Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells Am. Physiol. Regul. Integr. Comp. Physiol. 314(3):R427-R43, 2018. PMCID: PMC5899255
  34. George EM, Cockrell K, Arany M, Stec DE, Rimoldi JM, Gadepalli RS, Granger JP. Carbon monoxide releasing molecules blunt placental ischemia-induced hypertension. J. Hypertens. 30(9):931-937, 2017. PMCID:PMC5861582.
  35. Hosick PA, Weeks MF, Hankins MW, Moore KH, Stec DE. Sex-dependent effects of HO-1 deletion from adipocytes in mice. J. Mol. Sci.18(3)E611, 2017. PMCID:PMC5372627.
  36. Adeosun SO and Stec DE. Bilirubin protects the aging heart. Acta Physiol (Oxf), 220(4):402-403, 2017. PMCID:PMC5522653.
  37. Hinds TD Jr., Hosick PA, Chen S, Tukey RH, Hankins MW, Nestor-Kalinoski A, Stec DE. Mice with hyperbilirubinemia due to Gilbert’s Syndrome polymorphism are resistant to hepatic steatosis by decreases serine 73 phosphorylation of PPARa. J. Physiol. Endocrinol. Metab., 312(4):E244-E252, 2017. PMCID:PMC5406988.
  38. Marino JS, Stechschulte LA, Stec DE, Nestor-Kalinoski A, Coleman S, Hinds TD Jr. Glucocorticoid receptor β induces hepatic steatosis by augmenting inflammation and inhibition of the peroxisome proliferator-activated receptor (PPAR) α.J. Biol. Chem. 291 (50):25776-25788, 2016. PMCID:PMC5203696.
  39. Hinds TD Jr., Burns KA, Hosick PA, McBeth L, Nestor-Kalinoski A, Drummond HA, AlAmodi AA, Hankins MW, Vanden Heuvel JP, Stec DE. Biliverdin reductase A attenuates hepatic steatosis by inhibition of glycogen synthase kinase (GSK) 3b phosphorylation of serine 73 of peroxisome proliferator-activated receptor (PPAR) a. Biol. Chem. 291(48):25179-25191, 2016.PMCID:PMC5122784.
  40. Hinds TD Jr., Adeosun SO, Alamodi AA, Stec DE. Does bilirubin prevent hepatic steatosis through activation of the PPARa nuclear receptor? Medical Hypotheses. 95:54-57, 2016. PMCID:PMC5433619.
  41. Stec DE, John K, Trabbic CJ, Luniwal A, Hankins MW, Baum J, Hinds TD Jr. Bilirubin binding to PPARa inhibits lipid accumulation. PloS ONE 11(4):e0153427. Doi:10.1371/journal.prone.0153427, 2016. PMCID:PMC4829185.
  42. Ryan MJ, Coleman TT, Sasser JM, Pittman KM, Hankins MW, Stec DE. Vascular smooth muscle specific deletion of the leptin receptor attenuates leptin induced vascular relaxation. J. Physiol. Regul. Integr. Comp. Physiol. 310(10):R960-7, 2016. PMCID:PMC4896083.
  43. Stec DE, Juncos LA, Granger JP. Renal Intramedullary Infusion of Tempol Normalizes the Blood Pressure Response to Intrarenal Blockade of Heme Oxygenase-1 in Angiotensin II- Dependent Hypertension. Am. Soc. Hypertens. 10(4):346-351, 2016. PMCID:PMC4829442.
  44. Hosick PA, AlAmodi AA, Hankins MW, Stec DE. Chronic treatment with a carbon monoxide releasing molecule reverses dietary induced obesity in mice. Adipocyte 5:1-10, 2015. PMCID:PMC4836479.
  45. Lu Y, Wei J, Stec DE, Roman RJ, Ge Y, Cheng L, Liu EY, Zhang Z, Laerkegaard Hansen PB, Fan F, Juncos LA, Wang L, Pollock J, Huang PL, Fu Y, Wang S, Liu R. Macula densa nitric oxide synthase 1b protects against salt-sensitive hypertension. . J Am Soc Nephrol 27(8):2345-56, PMCID:PMC4829442.
  46. Hall ME, Harmancey R, Stec DE. Lean heart: Role of leptin in cardiac hypertrophy and metabolism. World Journal of Cardiology 7(9):511-524, 2015 .PMCID:PMC4577678.
  47. George EM, Stout JM, Stec DE, Granger Heme oxygenase induction attenuates TNF-a-induced hypertension in pregnant rodents. Front. Pharmacol. 6:165 doi: 10.3389/fphar.2015.00165. PMCID:PMC4538306.
  48.  Drummond HA and Stec DE. bENaC acts as a mechanosensor in renal vascular smooth muscle cells that contributes to renal myogenic blood flow regulation, protection from renal injury and hypertension. of Nephrology Res 1(1):1-9, 2015. PMCID:PMC5138029.
  49. O’Brien L, Hosick PA, John K, Stec DE, Hind Jr., TD. Biliverdin reductase isozymes in metabolism. Trends in Endocrinology and Metabolism. 26(4):212-220, 2015.PMCID: PMC4380527.
  50. Gannon KP, McKey SE, Stec DE, Drummond HA. Altered myogenic vasoconstriction and regulation of whole kidney blood flow in the ASIC2 knockout mouse. J. Physiol. Renal Physiol.308(4), F339-F348, 2015. PMCID:PMC4329487.
  51. Hall ME, Maready MW, Hall JE, Stec DE. Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation. J. Physiol. Endocrinol. Metab.,307(3),E316-25, 2014. PMCID:PMC4121577.
  52. Hosick PA, Ahmed EK, Gousset MU, Granger JP, Stec DE. Inhalation of carbon monoxide is ineffective as a long-term therapy to reduce obesity in mice fed a high fat diet. BMC Obesity: 1:6, 2014. PMCID:PMC4511028.
  53. Warrington JP, Coleman K, Skaggs C, Hosick PA, Stec DE, Ryan MJ, Granger JP, Drummond HA. Heme oxygenase-1 promotes migration and beta epithelial Na+ channel expression in cytotrophoblasts and ischemic placentas. J. Physiol. Regul. Integr. Comp. Physiol.306(9),R641-6 2014. PMCID:PMC4010664.
  54. Hosick PA, AlAmodi AA, Storm MV, Gousset MU, Pruett BE, Gray III W, Stout J, Stec DE. Chronic carbon monoxide treatment attenuates development of obesity and remodels adipocytes in mice fed a high-fat diet. J. Obesity 38(1):132-139, 2014. PMCID:PMC3760985.
  55. Stout JM, Gousset MU, Drummond HA, Gray III W, Pruett BE, Stec DE. Sex-specific effects of heme oxygenase-2 deficiency on renovascular hypertension. Am. Soc. Hypertens. 7(5):328-35, 2013. PMCID: PMC3783623.
  56. Stec DE, Storm MV, Pruett BE, Gousset MU. Antihypertensive actions of moderate hyperbilirubinemia: Role of superoxide inhibition. J. Hypertens. 26(7):918-23, 2013. PMCID:PMC3731819.
  57. George EM, Hosick PA, Stec DE, Granger JP. Heme oxygenase inhibition increases blood pressure in pregnant rats. J. Hypertens. 26(7):924-30, 2013. PMCID:PMC3731822.
  58. Hall ME, Smith G, Hall JE, Stec DE. Cardiomyocyte-specific deletion of leptin receptors causes lethal heart failure in Cre-recombinase mediated cardiotoxicity. J. Physiol. Regul. Integr. Comp. Physiol. 303(12):R1241-50, 2012. PMCID:PMC03532590
  59. Stec DE, Ishikawa K, Sacerdoti D, Abraham NG. Emerging role of heme oxygenase and its metabolites in the regulation of cardiovascular function. J. Hypertens. 2012;2012: 593530. Epub Oct 22, 2012. PMCID:PMC3485519
  60. Stec DE, Hosick PA, Granger. Bilirubin, renal hemodynamics, and blood pressure. Pharmacol. 3:18, 2012 (Epub Feb 14, 2012) PMCID: PMC3278997
  61. Stec DE, Drummond HA, Gousset MU, Storm MV, Abraham NG, Csongradi E. Expression of heme oxygenase-1in thick ascending loop of Henle attenuates angiotensin II-dependent hypertension. J Am Soc Nephrol 23(5): 834-841, 2012. PMCID:PMC3338287.
  62. Csongradi E, Juncos LA, Drummond HA, Vera T, Stec DE. Role of carbon monoxide in kidney function: Is a little carbon monoxide good for the kidney? Curr Pharm Biotechnol. 13: 819-826, 2012. PMCID:PMC3354025.
  63. Csongradi E, Storm MV, Stec DE. Renal inhibition of heme oxygenase-1 increases blood pressure in angiotensin-II dependent hypertension. J. Hypertens. 2012;2012:497213. Epub Nov 16, 2011. PMCID:PMC3227477.
  64. Chandrashekar K, Lopez-Ruiz A, Juncos R, Nath K, Stec DE, Vera T, Liu R, Juncos LA. The modulatory role of heme oxygenase on subpressor angiotensin II-induced hypertension and renal injury. J. Hypertens. 2012;2012:392890. Epub 2012 Mar 11. PMCID:PMC3312292.
  65. Hosick PA and Stec DE. Heme oxygenase, a novel target for the treatment of hypertension and obesity? J. Physiol. Regul. Integr. Comp. Physiol. 302:R207-214, 2012. PMCID:PMC3278997
  66. George EM, Aranay M, Cockrell K, Storm MV, Stec DE, Granger JP. Induction of heme oxygenase-1 attenuates sFlt-1 induced hypertension in pregnant rats. J. Physiol. Regul. Integr. Comp. Physiol. 301(5):R1495-500, 2011. PMCID: PMC3213946
  67. Rodriguez F, Lopez B, Perez C, Fenoy FJ, Hernandez I, Stec DE, Li Volti G, Garcia Salom. Chronic tempol treatment attenuates the renal hemodynamic effects induced by a heme oxygenase inhibitor in streptozotocin diabetic rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 301(5):R1540-8, 2011. PMCID:
  68. Drummond HA, Grifoni SC, Abu-Zaid A, Gousset M, Chiposi R, Barnard JM, Murphey B, Stec DE. Renal inflammation and elevated blood pressure in a mouse model of reduced bENaC. Am. J. Physiol. Renal Physiol.301(2):F443-9, 2011. PMCID:PMC3154591
  69. Csongradi E, doCarmo JM, Dubinion JH, Vera T, Stec DE. Chronic HO-1 induction with cobalt protoporphyrin (CoPP) treatment increases oxygen consumption, activity, heat production and lowers body weight in obese melanocortin-4-receptor-deficient mice. J. Obesity 36(2):244-53, 2012. PMCID: PMC3139690
  70. Hall ME, Smith G, Hall JE, Stec DE. Systolic dysfunction in cardiac specific ligand inducible MerCreMer transgenic mice. J. Physiol. Heart and Circulatory Physiology. 301(1):H253-60, 2011.PMCID: PMC3129917
  71. George EM, Cockrell K, Aranay M, Csongradi E, Stec DE, Granger JP. Induction of heme oxygenase 1 attenuates placental ischemia-induced hypertension. Hypertension. 57(5):941-8, 2011. PMCID: PMC3085942
  72. Salahudeen AK, Yang M, Huang H, Dore S, Stec DE. Fenoldopam preconditioning :role of heme oxygenase-1 in protecting human tubular cells and rodent kidneys against cold- hypoxia injury. Transplantation 91(2):176,182, 2011. PMCID: PMC3142452
  73. Cao J, Sodhi K, Inoue K, Quilley J, Rezzani R, Rodella L, Vanella L, Germinario L, Stec DE, Abraham NG, Kappas A. Lentiviral human heme oxygenase targeting endothelium improved vascular function in Ang II model of hypertension. Hum Gene Ther. 22:1-12, 2011. PMCID: PMC3057195
  74. Bardowell SA, Stec DE, Parker RS. Common variants of cytochrome P450 4F2 exhibit altered vitamin E-w-hydroxylase specific activity. Nutr. 140 (11):1901-6, 2010. PMCID: PMC2955872
  75. Vera T and Stec DE. Moderate hyperbilirubinemia improves renal hemodynamics in angiotensin II dependent hypertension. J. Physiol. Regul. Integr. Comp. Physiol. 299(4):R1044-9, 2010. PMCID:PMC2957382
  76. Csongradi E, Vera T, Rimoldi JM, Gadepalli RS, Stec DE. In Vivo Inhibition of Renal Heme Oxygenase with an Imidazole-Dioxolane Inhibitor.Pharmacol Res. 61(6):525-30, 2010. PMCID: PMC2859119
  77. Hall JE, da Silva AA, do Carmo JM, Dubinion J, Hamza S, Munusamy S, Smith G, Stec DE. Obesity-induced Hypertension: Role of Sympathetic Nervous System, Leptin andJ Biol Chem. 285(23):17271-6, 2010. PMCID:PMC2878489
  78. Stec DE, Vera T, Storm MV, McLemore Jr GR, Ryan MJ. Blood pressure and renal blood flow responses in heme oxygenase-2 knockout mice. J. Physiol. Regul. Integr. Comp. Physiol. 297(6):R1822-8, 2009. PMCID: PMC2803624
  79. Young SC, Storm MV, Speed JS, Kelsen S, Tiller CV, Vera T, Drummond HA, Stec DE. Inhibition of biliverdin reductase increases ANG II-dependent superoxide levels in cultured renal tubular epithelial cells. J. Physiol. Regul. Integr. Comp. Physiol. 297(5):R1546-53, 2009. PMCID: PMC2777783
  80. Vera T, Granger JP, Stec DE. Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates angiotensin-II dependent hypertension in mice. J. Physiol. Regul. Integr. Comp. Physiol. 297(3):R738-43, 2009. PMCID: PMC2739796
  81. Kelsen S, Patel BJ, Parker LB, Vera T, Rimoldi JM, Gadepalli RSV, Drummond HA, Stec DE. Heme Oxygenase Attenuates Angiotensin II-Mediated Superoxide Production in Cultured Mouse Thick Ascending Loop of Henle Cells. Am.J. Physiol. Renal Physiol. 295(4):F1158-65, 2008. PMCID:PMC2576158.
  82. Vera T, Kelsen S, Stec DE. Kidney-Specific Induction of Heme Oxygenase-1 Prevents Angiotensin II Hypertension. Hypertension. 52:1-6, 2008. PMCID:PMC2803055.
  83. Stec DE, Drummond HA, Vera T. Role of Carbon Monoxide in Blood Pressure
    Hypertension. 51:1-8, 2008.
  84. Stec DE, Vera T, McLemore GR, Kelsen S, Rimoldi JM, Gadepalli RSV, Ryan MJ. Heme oxygenase-1 induction does not improve vascular relaxation in angiotensin II hypertensive mice. J. Hypertens. 21(2):189-93, 2008. PMCID:PMC2849138.
  85. Zabalgoitia M, Colston JT, Reddy SV, Holt JW, Regan RF, Stec DE, Rimoldi JM, Chandrasekar B. Carbon monoxide donors or HO-1 overexpression block interleukin 18 mediated NF-kB-PTEN –dependent human cardiac endothelial cell death. Free Radical Biology and Medicine. 44:284-298, 2008. PMCID:PMC2576158.
  86. Asija A, Peterson SJ, Stec DE, Abraham NG. Targeting endothelial cells with heme oxygenase-1 gene using VE-Cadherin promoter attenuates hyperglycemia-mediated cell injury and apoptosis. Antioxidants & Redox Signaling 9(12):2065-73,
  87. Goodman AI, Olszanecki R, Yang LM, Quan S, Li M, Omura S, Stec DE, Abraham NG. Heme oxygenase-1 protects against radiocontrast-induced acute kidney injury by regulating anti-apoptotic proteins. Kidney Int. 72(8):945-53,
  88. Stec DE, Roman RJ, Flasch A, Rieder MJ. A functional polymorphism in human CYP4F2 decreases 20-HETE production. Physiological Genomics. 30(1):74-81,
  89. Vera T, Kelsen S, Yanes LL, Reckelhoff JF, Stec DE. HO-1 induction lowers blood pressure and superoxide production in the renal medulla of angiotensin II hypertensive mice. J. Physiol. Regul. Integr. Comp. Physiol. 292(4): R1472-8, 2007.
  90. Stec DE, Bishop C, Rimoldi JM, Poreddy SR, Vera T, Salahudeen AK. Carbon monoxide (CO) protects renal tubular epithelial cells against cold-rewarm apoptosis. Renal Failure. 29:1-6,
  91. Vera T and Stec DE. Heme Oxygenase-1: A potential anti-hypertensive target. Current Hypertension Reviews. 3(1): 75-82,
  92. Stec DE, Gannon KP, Beaird JS, Drummond HA. 20-Hydroxyeicosatetraenoic Acid (20- HETE) stimulates migration of vascular smooth muscle cells. Cell Physiol Biochem. 19:121-128,
  93. Olszanecki R, Rezzani R, Omura S, Stec DE, Rodella L, Botros F, Goodman AI, Drummond G, Abraham NG. Genetic suppression of HO-1 exacerbates renal damage: Reversed by an increase in the anti-apoptotic signaling pathway. J. Physiol. Renal Physiol. 292:F148-157, 2007.
  94. Granger JP, Abram S, Stec DE, Chandler D, LaMarca B. Endothelin, the Kidney,and Hypertension. Current Hypertension Reports. 8(4): 298-303,
  95. Grifoni SD, Gannon KA, Stec DE, Drummond HA. ENaC proteins contribute to VSMC migration. J. Physiol. Heart Circ Physiol. 291(6):H3076-86, 2006.
  96. Ryan MJ, Jernigan NL, Drummond HA, McLemore Jr., GR, Rimoldi JM, Poreddy SR, Gadepalli RSV, Stec DE. Renal vascular responses to CORM-A1 in the mouse. Pharmacol Res. 54(1):24-9,
  97. Drummond HA, Furtado MM. Myers S, Grifoni S, Parker KA, Hoover A, Stec DE. ENaC proteins are required for NGF-induced neurite growth. J. Physiol. Cell Physiol.290 (2):C404-C410, 2006.
  98. Tallam LS, Stec DE, Willis MA, da Silva AA, Hall JE. Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia. Hypertension 46(2): 326-332,
  99. Vera T, Henegar JR, Drummond HA, Rimoldi JM, Stec DE. Protective effect of carbon monoxide releasing compounds in ischemia-induced acute renal failure. J Am soc Nephrol 16: 950-958, 2005.
  100. Vera T, Taylor M, Bohman Q, Flasch A, Roman RJ, Stec DE. Fenofibrate prevents the development of angiotensin II-dependent hypertension in mice. Hypertension 45(2):730- 735,
  101. Stec DE. Smart Gene Therapy for the Heart. Hypertension 43:720-721,
  102. Stec DE , Flasch A, Roman RJ, White JA. Distribution of Cytochrome P450 4A and 4F isoforms along the nephron in mice. J. Physiol. Renal Physiol., 284:F95-F102, 2003.
  103. Zhu H, Paul IA, Stec DE, Peeler DF, Piletz JE. Non-adrenergic exploratory behavior induced by moxonidine at mildy hypotensive doses. Brain Research, 964:9-20,
  104. Stec DE, Keen HL, Sigmund CD. Lower blood pressure in floxed angiotensinogen mice after adenoviral delivery of Cre-recombinase. Hypertension. 39 (2 pt 2):629-633,
  105. Stec DE, Sigmund CD. Physiological insights from genetic manipulation of the renin- angiotensin system. News Physiol. Sci. 16: 80-84,
  106. Ding Y, Stec DE, Sigmund CD. Genetic evidence that lethality in angiotensinogen- deficient mice is due to loss of systemic but not renal angiotensinogen. Biol. Chem 276:7431-7436, 2001
  107. Sigmund CD and Stec DE. Genetic manipulation of the Renin-Angiotensin system using Cre-loxP-recombinase. In Methods in Molecular Medicine, vol. 51, Humana Press Inc., Totowa, NJ,
  108. Stec DE and Sigmund CD. Hypertension Research in the 21st Century:Tissue-specific deletion of gene function to study mechanisms of hypertension. Newsletter of the American Heart Association: Counsil for High Blood Pressure Research 1:16-19,
  109. Stec DE, Davisson RL, Haskill RL, Davidson BL, Sigmund CD. Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre- recombinase in vivo. Biol. Chem. 274 (30): 21285-21290, 1999.
  110. Davisson RL, Ding Y, Stec DE, Catterall JF, Sigmund CD. A novel mechanism of systemic hypertension: Activation of a tissue-restricted intrarenal renin-angiotensin system. Physiological Genomics 1:3-9,
  111. Stec DE, Sigmund CD. Modifiable gene expression in mice: Kidney-specific deletion of a target gene via the Cre-loxP system. Exp Nephrol 6:568-575,
  112. Stec DE, Davisson RL, Sigmund Transgenesis and gene targeting in the mouse. Trends Cardiovasc Med 8:256-264, 1998.
  113. Jiang J, Stec DE, Drummond HA, Simon JS, Koike G, Jacob HJ, Roman RJ. Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats. Hypertension 29:619-627,
  114. Stec DE, Mattson DL, Roman RJ. Inhibition of outer medullary 20-HETE production produces hypertension in Lewis rats. Hypertension 29 (1 pt.2):315-319,
  115. Wang MH, Stec DE, Balazy M, Matyugin V, Yang CS, Roman RJ, Schwartzman ML. Cloning, sequencing, and cDNA-directed expression of the rat renal CYP4A2:arachidonic acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein. Biochem. & Biophys. 336:240-250, 1996.
  116. Stec DE, Triolett MR, Krieger JK, Jacob HJ, Roman RJ. Cytochrome P4504A activity and salt-sensitive hypertension in spontaneously hypertensive rats. Hypertension 27:1329- 1336,
  117. Stec DE, Deng AY, Rapp JP, Roman RJ. Cytochrome P4504A cosegregates with hypertension in Dahl S rats. Hypertension 27(pt.2): 564-568,
  118. Imig JD, Gebremedhin D, Zou AP, Stec DE, Harder DR, Roman RJ. Formation and actions of 20-hydroxyeicosatetraenoic acid in the renal microcirculation. J. Physiol. R217-R227, 1996.
  119. Lezin EM, Pravenec M, Wong AL, Liu W, Wang N, Lu S, Jacob HJ, Roman RJ, Stec DE, Wang JM, Reid IA, Kurtz TW. Effect of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl Salt-Resistant rats. J. Clin. Invest. 97:522-527, 1996.
  120. St. Lezin EM, Pravenec M, Wong A, Wang JM, Merriouns T, Newton S, Stec DE, Roman RJ, LauD, Morris RC, Kurtz TW. Genetic contamination of Dahl SS/Jr rats: impact on studies of salt-sensitive hypertension. Hypertension 23:786-790, 1994.

Complete List of Published Work in My Bibliography https://www.ncbi.nlm.nih.gov/sites/myncbi/david.stec.2/bibliography/40816641/public/?sort=date&dire ction=descending

Research Support

ACTIVE:

1R01DK121748-01A1- DE Stec         4/1/2020-3/30/2025
NIH-NIDDK
"Integrative Role of Bilirubin on Obesity"
Role: Principal Investigator-1.8 person months per year.

1R01DK121748-01A1 -TD Hinds       7/1/2020-6/30/2025 NIH-NIDDK
"Novel Liver Signaling Pathways Controlling Adiposity" Role: Co-Investigator-1.2 person months per year